Peptide Referee

PE-22-28: research, legal status and who sells it

This page is information, not medical advice. PE-22-28 is not approved as a medicine in the markets below unless stated. We don't publish dosing or usage instructions.

Also known as
PE 22-28
Category
Synthetic 7-amino-acid analogue of spadin, a peptide that blocks the TREK-1 potassium channel
Evidence level
Preclinical (lab and animal studies)
Price range
$3.40/mg to $10.00/mg, median $5.00/mg across 23 vendors (compare)
Our lab tests
None yet (how testing will work)
WhereStatus
United StatesNo FDA-approved drug contains PE-22-28 [1].
United KingdomNo UK-licensed medicine containing PE-22-28 appears in the MHRA products database [2].
European UnionNo medicine containing PE-22-28 is authorized in the EU, according to EMA's central and Article 57 product data [3][4].
CanadaNo product containing PE-22-28 appears in Health Canada's Drug Product Database [5].
AustraliaPE-22-28 is not named in Australia's Poisons Standard (October 2026) [6].
Sport (WADA)Not named on the 2026 Prohibited List; its section S0 bans any pharmacological substance with no current approval for human therapeutic use [7].
 Summaries of official sources, checked —. Rules change; follow the source links. Not legal advice.

We haven't published a full overview of PE-22-28 yet. The legal status table and live prices on this page are current.

PE-22-28 prices: cheapest listings

The five lowest $/mg listings out of 25. See all PE-22-28 prices

Vendor Transparency Product Size Price $/mg vs median Stock Vendor's page
Iron Aminos 40/100* PE-22-28 10MG 10 mg × 10 $340 $3.40/mg −32% In stock View
Polaris Peptides 45/100 PE 22-28 13mg 13 mg $45 $3.46/mg −31% In stock View
Iron Aminos 40/100* PE-22-28 10MG 10 mg $40 $4.00/mg −20% In stock View
Bulk Peptide Wholesale 45/100* PE-22-28 5mg (10 vials) 5 mg × 10 $200 $4.00/mg −20% In stock View
Peptide Plugs 57/100* PE-22-28 10mg 10 mg $40 $4.00/mg −20% In stock View

Prices come from each vendor's public product feed and were last fetched Oct 15, 2026. They exclude shipping and discounts. $/mg uses the labeled amount, not measured content. A transparency score marked * is based on fewer than six checks; checks we couldn't complete score 0. How we compare prices.

Sources

  1. Drugs@FDA: FDA-Approved Drugs (database searched by active ingredient). U.S. Food and Drug Administration. Accessed Oct 15, 2026
  2. MHRA Products: licensed-medicine search for "pe-22-28". Medicines and Healthcare products Regulatory Agency (UK). Accessed Oct 15, 2026
  3. EMA medicines data: centrally authorised human medicines (export of 14 October 2026). European Medicines Agency. Accessed Oct 15, 2026
  4. EMA Article 57 product data: medicines authorised in the EU/EEA (data as of 9 October 2026). European Medicines Agency. Accessed Oct 15, 2026
  5. Drug Product Database online query (searched by active ingredient). Health Canada. Accessed Oct 15, 2026
  6. Therapeutic Goods (Poisons Standard—October 2026) Instrument 2026 (F2026L01327, registered 30 September 2026). Federal Register of Legislation, Australian Government. Accessed Oct 15, 2026
  7. World Anti-Doping Code International Standard: Prohibited List 2026 (in force 1 January 2026). World Anti-Doping Agency. Accessed Oct 15, 2026
  8. Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity. Frontiers in Pharmacology (2017). Accessed Oct 15, 2026